Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

Andrews explores spiritual practices that were the vital source from which everything else about Transcendentalism-texts, ideas, and social action-flowed. These practices are eminently available to spiritual seekers today, both those who are connected to conventional forms of religiosity and those who are allergic to 'religion.

Three characteristic problems in the measurement of corporate social performance (CSP) center around the need to measure three “metrics”: the metric of performance evaluation (M1), the metric of performance measurement (M2), and the metric of performance perception and belief (M3). The central issues in each metric are commitment, revelation, and belief, respectively. This article discusses each metric and provides sets of theoretical propositions under M2 and M3 describing behavior in those contexts. Some of the propositions inM2form an explicit partial theory (...) of factors affecting the likelihood of CSP measurement. Those under M3 are developed from more general ones in the theory of testaments. (shrink)

Craig, Barry M As we return from the Lent-Easter cycle to Ordinary Time, the last Sunday of which was the Sixth, on 15 February, we pick up on the Eleventh Sunday and so miss chapters 2 and 3 of Mark. For six Sundays this quarter we will read from chapters 4 to 6, but at the point of his first account of the feeding of a multitude we will switch to John to lead into the four Sundays of his Bread (...) of Life discourse - a valuable detour, but one that inhibits a more thorough reading of Mark. (shrink)

Craig, Barry M A characteristic feature of Luke's Gospel is that of the journey, with Jesus from chapter 9 resolutely heading to Jerusalem; of the more than eighty verses naming Jerusalem in the New Testament only a handful are not in Luke-Acts. Last Sunday's gospel reading was taken from the last day of teaching given after entering Jerusalem and reclaiming the Temple, and before the Passover and arrest. But Jesus is not the only one to whom the journey motif applies. (...) Last Sunday reference was made to the Son of Man coming in power, and the exhortation to the disciples to stand ready is akin to that of people prepared for a journey. Today we return to just before the commencement of the public ministry, with John the Baptist exhorting people to prepare a way for the Lord. A simple reading of this text suggests that it is the way on which God proceeds that needs making straight, but it is not: it refers to the path on which those God rescues are brought in procession. This is the procession referred to in the second reading, for which mountains are levelled and the valleys filled so that Jerusalem's captive children may be brought back safely from the land of bondage, Babylon. (shrink)

Craig, Barry M The combination of 'the eyes of the blind shall be opened' in Isaiah 35:5 and the psalm's 'the Lord gives sight to the blind' seems to be preparing the way for an account of the restoration of sight in the gospel, but its focus is instead on restoring hearing and speech. In this story, which is shared with Matthew, as with the raising of the young girl told also by Matthew and Luke, Mark alone reports the Lord's (...) command in Aramaic. In this case the Lord's word is transmitted in Greek transliteration as Ephphatha, but correctly it should be Ethphathach. The mispronunciation perhaps points to a particular fascination with the Lord's own words in Mark's Greek-speaking circles, and also to the attribution of magical power to such words that may then be borrowed in magical folk-medicine; think similarly of the conjectured origin of Hocus pocus in Hoc est Corpus from Mass in Latin. However, the Aramaic word is richly connected to the mission of Jesus. In the first reading, the Hebrew has two synonymous verbs in verse 5 for opening, respectively applied to the eyes of the blind and the ears of the deaf. The first is not common and is always said of eyes, except in Isaiah 42:20, where it is used of ears. The second verb is common and refers to the opening of eyes and ears and mouths, but also to the untying of cords and to setting free. This is clear in the Syriac Peshitta's use of a single verb for both Hebrew verbs in Isaiah and the word Mark reports Jesus using, where it is applicable both to opening the man's ears to hear and to freeing his tongue to speak clearly. The Septuagint's version of Isaiah has 'will hear' instead of the Hebrew's second verb, 'will be opened', while the added translation in Mark matches only the Septuagint's translation of Isaiah's first verb. That Greek verb is fitting only for the ears, not for the tongue, so that the man's becoming able to speak clearly seems to be merely a consequence of the miraculous opening of his ears. Reading both passages via the Syriac, and reading them in parallel as the Lectionary has us do today, reveals the gospel encounter to be more than simply a story of a healing: the episode points to Christ's redeeming mission as being one of liberating, the scene becoming a fulfilment of Isaiah's prophetic passage in a demonstration of Christ's mission in the flesh and in the life of an actual person. Furthermore, Mark's transmission of the Aramaic commands Ethphathach and Kum in 5:41, together sum up Christ's twofold work: to redeem and raise those doomed to die. Both stories show this at work in the here and now of people's lives and not merely as a future hope for the end of time. If our mission as Church is to continue Christ's work, then it is likewise to be carried out among people in our own time. Thus the historical impetus to establish such works as schools, since education sets free from ignorance, and hospitals, since curing the sick frees them from ills or caring for them brings relief in time of suffering. But we should not think only in such institutional modes; not every parish can or should establish a school or hospital or hospice, or other such major works, but the question remains for each: What does this community do to proclaim Christ's saving mission in the lives of real people both near and far? (shrink)

Craig, Barry M Today's gospel reading includes one of the eleven parables unique to Luke; it is also one of the most well known, and is often said to be misnamed in its common designation as the Prodigal Son. Many parables are similarly named in ways that appear to miss the point of their telling, but this tendency actually points to how we engage with all stories, and the power of Christ's storytelling. We need to realise that the mind does (...) not distinguish between reality and fiction, for all viewing and understanding of the world takes place in our heads. Thus we respond emotionally and even physically in the same way to what we see unfolding, be it real-time events in the world or depicted events, historical or fictional, as mediated by actors and machinery at the movies. In the same way, we do not distinguish between reports of actual happenings and fictional stories. Should there be any doubt about this, ask yourself: Have I ever cried at a movie, or laughed, or grown angry, or felt anything, or ducked, jumped or reacted in any way at all? At a recent viewing of Les Miserables someone at the end of the row was overcome with uncontrollable sobbing as the movie drew to an end. This distraction provided suitable cover for not a few people to sneak hankies out of pockets and return them before lights returned. If we did not respond to movies there would be no point in seeing them. Similarly with novels. They are also fodder for our imaginations, where we in a sense try on the experiences of others, imaginatively inhabiting the bodies and feelings of others. This is the basis of empathy, and the source of the power of storytelling. (shrink)

Craig, Barry M Our last Sunday in Ordinary Time before Lent was the Fifth ; we were in Luke's fifth chapter when the first disciples were called. We now return to the Sundays in Ordinary Time, picking up on the Tenth Sunday and two chapters later, and so we begin our first sustained reading from Luke's gospel, chapters 7 to 14, but skip all but the opening verses of chapter 8. Jesus' Galilean ministry occupies until the end of chapter 9, (...) then he begins the procession to Jerusalem, during which various teachings are located without being specific to the journey. (shrink)

Craig, Barry M As we return from the Lent-Easter cycle to Ordinary Time, the last Sunday of which was the Sixth, on 15 February, we pick up on the Eleventh Sunday and so miss chapters 2 and 3 of Mark. For six Sundays this quarter we will read from chapters 4 to 6, but at the point of his first account of the feeding of a multitude we will switch to John to lead into the four Sundays of his Bread (...) of Life discourse - a valuable detour, but one that inhibits a more thorough reading of Mark. (shrink)

Craig, Barry M Several solemnities fall on Sundays this year, displacing the usual readings and prayers. Three occur in this period, Sundays 24, 31 and 32, giving way respectively to Exaltation of the Holy Cross, All Saints and Commemoration of All the Faithful Departed, and Dedication of the Lateran Basilica. A further complication is that All Saints outranks All Souls, so Mass on Saturday evening is of All Saints, not of All Souls, just as when Christmas falls on a Saturday, (...) the evening Mass is of Christmas not the Holy Family. This results in disruption to the Lectionary, and some repetitions. For Holy Cross, the second reading, which is also read on Good Friday, reappears two weeks later unless the shorter form is used; and the gospel was part of that read on Trinity Sunday. On All Souls readings are to be chosen from the Lectionary's provision for Masses for the Dead. For convenience, a set is provided in the Sunday book, but its first reading repeats all but the last phrase from three weeks earlier, and much of the second reading was read on the third Sunday in Lent, while the gospel has also already been read. So, for All Souls this year parishes are advised to exercise the prerogative to choose readings, for which reason no reflection can be given here that may cover all. (shrink)

Craig, Barry M The season of Advent is not well-defined as it flows almost seamlessly from the end-time themes of the Sundays late in Ordinary Time and turns to the approaching Nativity of Christ. Lacking an event-defining start, Advent in the Roman Rite is named as the four Sundays before Christmas, thus lasting twentyone to twenty-eight days, while in the Ambrosian Rite of Milan it is six Sundays. The elements common to each Sunday's gospel reading in the Roman Rite's three-year (...) Lectionary reveal this sequence: Stay awake; John the Baptist is a voice crying in the wilderness 'Prepare a way for the Lord'; John the Baptist is a witness to Christ; Annunciation to Joseph, or to Mary, or the Visitation -in any case Mary is with child. Although this year, B, we follow the Gospel according to Mark, after reading its opening on the Second Sunday of Advent we do not read from it again until the feast of the Baptism of the Lord. Thus the Lectionary for Advent and Christmastide presents a melange of all four Gospels, with Mark the least represented. This is unavoidable since Mark provides no information from before the emergence of Jesus in his public ministry. However, homilists need to remember that this socalled year of Mark will have several interruptions from John's Gospel. (shrink)

Craig, Barry M Review of: Vatican council II: Reforming liturgy, by Carmel Pilcher, David Orr and Elizabeth Harrington, eds., pp. xxviii + 307, $49.95.

Malaria is a disease of developing countries whose local health services do not have the time, resources or personnel to mount studies of drugs or vaccines without the collaboration and technology of western investigators. This investigative collaboration requires a unique bridging of cultural differences with respect to human investigation. The following debate, sponsored by The Institute of Medicine and The American Society of Tropical Medicine and Hygiene, raises questions concerning the conduct of trans-cultural clinical malaria research. Specific questions are raised (...) about the difficulties of informed consent in different cultural settings and whether there is any role for community involvement. Discussants debate whether drug and vaccine trials not approved in an industrialised country are ever defensible if performed in a third-world setting. Potential conflicting priorities between investigators are discussed and ideas regarding conflict resolution are offered. (shrink)

The concept of scientific field lacks a definition in a form allowing the distinction of whether a particular academic area of study is or is not a true scientific field. Starting with the classic definition by Whitley of a field as a “reputational work organization,” this essay extracts eleven explicit and implied features of a field from Whitley’s definition and discussion, extending his analysis. The article reviews Hambrick and Chen’s model of field formation as an “admittance-seeking social movement.” Hambrick and (...) Chen argue that strategic management followed that model with success, offering the SIM Division of the Academy of Management as an unsuccessful example. The article notes errors in their assessment of SIM, argues that Hambrick and Chen are really offering a model of what I term condensation and promulgation of a field and that their model cannot be used to determine whether a field exists. The article applies the extended Whitley model of a field to examine three candidate fields within SIM: corporate social responsibility (CSR)/corporate social performance (CSP), stakeholder theory, and corporate political activity (CPA). I conclude that none is technically a field, and considering as well the comments of three senior scholars who contributed to the symposium, the article discusses the potential trajectory of fields in SIM. (shrink)

A normative criterion identifying the conditions for a desirable corporate reputation, “reputational optimality,” or “reputational bliss,” is described, and a case developed for its utility and reasonableness as a criterion to apply to real world phenomena. The paper discusses some behavioral patterns under alternative moral positions taken by observers and the firm, critiques some alternative moral principles, and considers some dynamics of moving toward, defending and maintaining, and breaching or breaking reputational bliss.

BackgroundThe widespread sharing of biological and biomedical data is recognised as a key element in facilitating translation of scientific discoveries into novel clinical applications and services. At the same time, twenty-first century states are increasingly concerned that this data could also be used for purposes of bioterrorism. There is thus a tension between the desire to promote the sharing of data, as encapsulated by the Open Data movement, and the desire to prevent this data from ‘falling into the wrong hands’ (...) as represented by ‘dual use’ policies. Both frameworks posit a moral duty for life sciences researchers with respect to how they should make their data available. However, Open data and dual use concerns are rarely discussed in concert and their implementation can present scientists with potentially conflicting ethical requirements.DiscussionBoth dual use and Open data policies frame scientific data and data dissemination in particular, though different, ways. As such they contain implicit models for how data is translated. Both approaches are limited by a focus on abstract conceptions of data and data sharing. This works to impede consensus-building between the two ethical frameworks. As an alternative, this paper proposes that an ethics of responsible management of scientific data should be based on a more nuanced understanding of the everyday data practices of life scientists. Responsibility for these ‘micromovements’ of data must consider the needs and duties of scientists as individuals and as collectively-organised groups.SummaryResearchers in the life sciences are faced with conflicting ethical responsibilities to share data as widely as possible, but prevent it being used for bioterrorist purposes. In order to reconcile the responsibilities posed by the Open Data and dual use frameworks, approaches should focus more on the everyday practices of laboratory scientists and less on abstract conceptions of data. (shrink)

In Sandra Waddock’s article “Taking Stock of SIM” in this journal, she identifies key issues in the work of the Social Issues in Management (SIM) Division of the Academy of Management. This article challenges her analysis of SIM scholarship and her arguments of what is necessary for the division to progress. Scholarship in SIM should emphasize two key streams: First, scholars in SIM should seek to develop a science of social forensics, design, and social repair—in essence, develop a method of (...) problem diagnosis, an approach to practical solution design, and a systematic understanding of the selection and implementation of social repair—in other words, seek to understand how to systematically troubleshoot and engineer solutions to fundamental issues in the business and society interface. The second stream, which informs the first, involves the development of original, core, transferable systematics that can “travel”—be the source of understanding-generating analysis—in other disciplines, including the topical regions of the Academy of Management. The article argues that laying claim to and developing true normative theory applicable across disciplines should be a distinctive identifier of work in SIM. The article concludes with an illustration of how systematics can be applied to address the literature’s failure to even seek to understand the logic underlying the standard ethical theories. These theories are properly seen as complements rather than substitutes. We need to ask and answer the “fundamental question of business ethics”: What should I do?.We suggest an approach labeled “integrative ethics,” employing ethical frames/injunctive formats, framed contexts for action, and the distribution of desires. (shrink)

On October 23, 1965, Theodor Adorno delivered a lecture to the German Werkbund in Berlin in which he addressed the relation between the supposedly “fine” and the so-called “applied” arts—a polarity he finds highly problematical. This essay analyzes Adorno’s discourse in the context both of the German Werkbund and subsequent developments in design and design theory. We conclude with some reflections on the meaning of functionalism today.

In the first, sweeping volume of The Venture of Islam, the late Marshall Hodgson recalls the Riddah Wars, fought in the 7th century between the brethren over the right to transmit the true legacy of the Prophet. Herbert Marcuse is as far from Mohammed as the deserts of America are from those of Arabia, but since his death in 1979, the familiar archetype has been playing itself out. At the head of the legions of the faithful rides the indomitable Douglas (...) Kellner, who for years has waged a single-minded campaign to clear the field of competition. Kellner has always concluded his polemics with a promise: the damage these pretenders have wrought is not yet irreversible, consequently, “Marcuse's legacy still awaits comprehensive and systematic treatment,” “an adequate appraisal of Marcuse's thought and legacy remains to be done.”. (shrink)

torts raise a number of interesting and perplexing philosophical issues. In a suit for ‘wrongful life’, the plaintiff (usually an infant) brings an action (usually against a physician) claiming that some negligent action has caused the plaintiff's life, say by not informing the parents of the likely prospect that their child would be born with severe defects. The most perplexing feature of this is that the plaintiff is claiming that he would have been better off if he had never been (...) born. A number of arguments have appeared which purport to show that ‘wrongful life’ claims should not be allowed, either because it is senseless to claim that one would be better off if one had not existed or that it is impossible to assess the extent to which someone has been damaged by being brought into existence. In our paper we rebut these arguments and suggest a procedure for determining damages in ‘wrongful life cases’. Keywords: ‘wrongful life’, ‘wrongful birth’, negligence, impaired existence, assessing damage * Professor Bell would like to express appreciation to the National Endowment for the Humanites for affording her the opportunity at an NEH Summer Seminar to do most of the background work for the preparation of this manuscript, and to the South Carolina Committee for the Humanities for funding that aided in continued work on this topic. CiteULike Connotea Del.icio.us What's this? (shrink)

Executive functions (EFs) and impulsivity are dimensions of self-regulation that are both related to psychopathology. However, self-report measures of impulsivity and laboratory EF tasks typically display small correlations, and existing research indicates that impulsivity and EFs may tap separate aspects of self-regulation that independently statistically predict psychopathology in adulthood. However, relationships between EFs, impulsivity, and psychopathology may be different in childhood compared to adulthood. Here, we examine whether these patterns hold in the baseline assessment of the Adolescent Brain and Cognitive (...) Development (ABCD) sample, a national sample of over 11,000 children (including 749 twin pairs) ages 9–10 years. We examine the phenotypic and genetic relationships among latent variables for different components of EFs and multiple facets of impulsivity. Additionally, we assess how EFs and impulsivity relate to composite measures and latent variables of psychopathology derived from parent report. EFs were weakly correlated with impulsivity, and the strength varied by impulsivity facet, emphasizing their separability. We did not identify significant genetic and environmental correlations between EFs and impulsivity. Moreover, controlling for their small relationships with each other, both EFs and some facets of impulsivity statistically predicted an Externalizing factor, attention problems, and social problems, and twin analyses suggested these relationships were genetic in origin. These findings indicate that EFs and impulsivity represent phenotypically and genetically separable aspects of self-regulation that are both transdiagnostic correlates of psychopathology in childhood. (shrink)

Cyclic nucleotides can regulate the sensitivity of retinal rods to light through phosducin. The phosphorylation state of phosducin determines the amount of G available for activation by Rho*. Phosducin phosphorylation is regulated by cyclic nucleotides through their activation of cAMP-dependent protein kinase. The regulation of phosphodiesterase activity by the noncatalytic cGMP binding sites as well as Ca2+/calmodulin dependent regulation of cGMP binding to the cation channel are also discussed.